Why Does Antidepressants Make You Tired?

DelindaMedina 20 May 2023

Antidepressants are medications used to treat depression, anxiety, and other mental health conditions. They work by altering the levels of certain neurotransmitters in the brain, such as serotonin and dopamine. While these drugs can be effective in treating these conditions, they can also have side effects. One of the most common side effects is fatigue or feeling tired.

But why does this happen? In order to make an informed decision about whether or not to take antidepressants, it’s important to understand why they make you tired.

One possible explanation is that antidepressants interfere with the body’s natural sleep-wake cycle. Serotonin and dopamine are neurotransmitters that help regulate our circadian rhythm (our internal clock). When these neurotransmitters are disrupted by antidepressants, it can lead to a disruption in our sleep-wake cycle which can cause fatigue.

Another reason antidepressants might cause fatigue is because they affect our energy levels. Antidepressants can alter our metabolism and how quickly we use up energy stores in our bodies. This can lead to feelings of exhaustion and lack of motivation throughout the day.

some people experience a “paradoxical reaction” when taking antidepressants where instead of feeling better, they feel worse. This reaction can include increased fatigue as well as other symptoms such as irritability or agitation.

It’s important to remember that everyone reacts differently to medication and there is no one-size-fits-all answer when it comes to understanding why antidepressants make you tired. If you are considering taking antidepressants, talk to your doctor about potential side effects so that you can make an informed decision about whether they are right for you or not.

What are the Different Types of Antidepressants?

Have you ever taken an antidepressant and found yourself feeling more tired than usual? You’re not alone. Fatigue is a common side effect of taking antidepressants, but why does this happen?

It turns out that there are several potential causes for this fatigue. For starters, antidepressants can disrupt the body’s natural sleep-wake cycle, leading to insomnia or excessive daytime sleepiness. Additionally, antidepressants can alter the person’s metabolism, which can lead to feelings of tiredness.

There are several different types of antidepressants available on the market today. SSRIs (Selective Serotonin Reuptake Inhibitors) are some of the most commonly prescribed medications and work by increasing serotonin levels in the brain. SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors) work similarly to SSRIs but also affect norepinephrine levels in the brain. Tricyclic Antidepressants were developed before SSRIs and SNRIs and block the reabsorption of neurotransmitters like serotonin and norepinephrine. MAOIs (Monoamine Oxidase Inhibitors) block an enzyme called monoamine oxidase which breaks down neurotransmitters like serotonin and norepinephrine. Atypical Antidepressants don’t fit into any of these categories but are still used to treat depression.

It’s important to remember that everyone experiences side effects differently, so it’s important to talk to your doctor about any concerns you may have regarding taking antidepressants or any other medications.

How Do Antidepressants Cause Drowsiness and Fatigue?

Depression is a serious mental health condition that can take a toll on your overall wellbeing. It affects people of all ages and from all walks of life, and can have a significant impact on your quality of life. Fortunately, there are treatments available to help manage the symptoms of depression, including medications known as antidepressants. While these medications can be effective in treating depression, they can also cause drowsiness and fatigue.

So how do antidepressants cause drowsiness and fatigue? The most common type of antidepressant is a selective serotonin reuptake inhibitor (SSRI). These medications work by increasing levels of serotonin – a neurotransmitter that helps regulate mood, sleep, and appetite – in the brain. When SSRI levels are increased, it can lead to feelings of drowsiness and fatigue as the body adjusts to the change in serotonin levels.

Other types of antidepressants may also cause drowsiness and fatigue due to their effects on other neurotransmitters such as norepinephrine and dopamine. Additionally, certain side effects associated with taking antidepressants may contribute to drowsiness or fatigue, such as dry mouth or constipation. Some medications used to treat depression may also interact with other medications or substances that can further contribute to drowsiness or fatigue.

It’s important to talk to your doctor if you experience any side effects from taking antidepressants so they can adjust your dosage or switch you to another medication if necessary. With proper treatment and support from friends and family, it is possible for those living with depression to lead healthy lives free from symptoms like drowsiness and fatigue caused by antidepressants.

SSRIs and SNRIs: The Most Common Types of Antidepressants

When it comes to managing depression, antidepressants can be a helpful tool. But why do they make you so tired?

The two most common types of antidepressants are SSRIs (selective serotonin reuptake inhibitors) and SNRIs (serotonin-norepinephrine reuptake inhibitors). SSRIs work by increasing the amount of serotonin in the brain, which helps to improve mood and reduce anxiety. Commonly prescribed SSRIs include Prozac, Zoloft, Paxil, and Lexapro.

SNRIs increase both serotonin and norepinephrine in the brain, which can help with symptoms of depression and anxiety. They are usually prescribed for more severe forms of depression or when other antidepressants have not been effective. Commonly prescribed SNRIs include Cymbalta, Effexor, and Pristiq.

Both types of medications can cause drowsiness or fatigue as a side effect in some people. This is especially true if you are taking higher doses or combining multiple medications together. It’s important to talk to your doctor about any side effects you experience while taking these medications so that they can adjust your dosage if needed.

It’s also important to remember that even though antidepressants can make you feel tired at first, they can be an essential part of managing depression over time. If you find yourself feeling overly fatigued after starting an antidepressant medication, don’t give up yet – talk to your doctor about adjusting your dosage or trying another type of medication altogether. With the right combination of treatment options, you may find relief from your depression without feeling overly tired all the time!

Is My Antidepressant Making Me Feel Tired?

Are you feeling unusually tired lately? Could it be that your antidepressant is making you feel exhausted? It’s possible, as certain types of antidepressants can cause drowsiness or fatigue as a side effect. While this is usually only temporary, it’s important to talk to your doctor if you think your medication is causing fatigue.

Common antidepressants that may cause fatigue include selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). If you’re taking one of these medications and experiencing fatigue, the symptoms may include feeling tired all the time, having difficulty staying awake during the day, and needing more sleep than usual. Other side effects of antidepressants such as decreased motivation, lack of energy, and decreased libido can also contribute to feelings of tiredness.

The severity of antidepressant-induced fatigue can vary from person to person and is often dose-dependent, higher doses are more likely to cause fatigue. If you think your antidepressant is making you feel tired, it’s important to speak with a doctor about adjusting the dosage or switching medications if necessary. They will be able to help determine whether or not the medication is causing your exhaustion and provide guidance on what steps should be taken next.

It’s normal to feel fatigued every now and then—especially during times of stress—but if you think your antidepressant might be contributing to your exhaustion, don’t hesitate to reach out for help. Speak with a medical professional so they can assess whether or not the medication could be causing your fatigue and suggest ways in which it can be managed effectively.

How Do Antidepressants Impact Sleep Quality?

When it comes to managing depression, many people turn to antidepressants. But did you know that certain types of antidepressants can actually make you feel tired? It’s true – and the impact on your sleep quality can be significant.

It is estimated that up to 70% of people who take antidepressants experience changes in their sleep patterns. Common side effects include insomnia, nightmares, and restlessness. Some types of antidepressants may even cause increased alertness during the night, making it difficult for you to fall asleep or stay asleep.

On the other hand, some antidepressants can cause drowsiness and fatigue, which may lead to oversleeping or difficulty waking up in the morning. It all depends on the type of antidepressant used and individual factors such as age and lifestyle habits.

If you’re taking antidepressants and have noticed changes in your sleep quality, it’s important to discuss this with your doctor. They can help adjust your dosage or switch medications if necessary – so you can get a good night’s rest without worrying about feeling too tired during the day!

Treating Insomnia with Low-Dose Antidepressants

Insomnia can be a frustrating and exhausting issue, but there are treatments available to help. Low-dose antidepressants, such as trazodone, are commonly used to treat insomnia. They work by reducing the amount of time it takes to fall asleep and improving the quality of sleep.

These medications can be an effective short-term solution for those struggling with insomnia, but they should not be used as a long-term fix due to potential side effects. Common side effects include dry mouth, drowsiness, dizziness, headache, nausea and blurred vision. It’s important to discuss any risks or interactions with a doctor before taking low-dose antidepressants for insomnia.

In addition to low-dose antidepressants, other treatments like cognitive behavioral therapy (CBT) and relaxation techniques can also be helpful in treating insomnia. Combining these treatments with low-dose antidepressants may be beneficial for some people who are struggling with persistent sleep issues.

No matter what treatment you choose for your insomnia, it’s important to remember that everyone is different and what works for one person may not necessarily work for another. Be sure to consult your doctor if you have any questions or concerns about using low-dose antidepressants or any other treatment option.

Strategies to Combat Tiredness from Antidepressants

Do you find yourself feeling tired all the time, even after a full night’s sleep? If so, it could be a side effect of taking antidepressants. While fatigue is a common symptom of depression, it can also be caused by the medication itself. Fortunately, there are strategies to help combat tiredness from antidepressants.

First and foremost, exercise can be an effective way to boost energy levels. Regular physical activity helps release endorphins that give you a natural energy boost. Eating a balanced diet with plenty of fruits and vegetables is another great way to increase your energy levels. Caffeine in moderation can also help fight fatigue – but be careful not to overdo it!

Getting enough quality sleep at night is essential for fighting tiredness. Try setting up a consistent bedtime routine that helps you relax before sleeping. Herbal supplements such as ginseng and ashwagandha have been shown to have energizing effects on the body, so consider adding these into your daily routine as well. Taking breaks throughout the day and engaging in activities that you enjoy can also help keep your energy levels up.

If you’re still having trouble with fatigue while taking antidepressants, consult your doctor about treatments for insomnia such as low-dose antidepressants or cognitive behavioral therapy (CBT). These treatments may offer relief without any additional side effects – but always check with your doctor first before trying any new medications or therapies!


Fatigue is a common side effect of taking antidepressants, and it can impact your overall wellbeing. Depression is a serious mental health condition that can cause drowsiness and fatigue, and the medications used to treat it can also be the cause. Different types of antidepressants can lead to fatigue in different ways, from disrupting the body’s natural sleep-wake cycle to altering metabolism.

Some types of antidepressants may cause changes in sleep patterns, such as insomnia, nightmares, or fatigue. In some cases, this side effect may be temporary and require adjusting the dosage or switching medications. For those who experience persistent fatigue despite medication changes, there are treatments available for insomnia that may help alleviate symptoms. Low-dose antidepressants and cognitive behavioral therapy are two options that have been proven effective but may come with their own side effects. It’s important to consult your doctor before choosing any treatment option.

If you’re on antidepressants and feeling fatigued all the time, there are steps you can take to help alleviate symptoms. Exercise, eating a balanced diet, and getting enough quality sleep are essential for managing fatigue. Additionally, supplements and therapies can also provide relief. If none of these strategies make a difference in how you’re feeling, talk to your doctor about other options they may suggest.


Hello, my name is Delinda Medina and I am a 30-year-old female with a medical background and nursing experience. I am passionate about sharing my knowledge and insights into the medical field, and I have found writing articles about medicine to be an enjoyable and rewarding hobby. Currently residing in Beverly, US, I am excited to continue learning and exploring the ever-evolving world of healthcare while sharing my insights with others.

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